【Abstract】 Objective To investigate the predictive value of amplitude-integrated electroencephalography (aEEG) combined with cranial magnetic resonance imaging (cMRI) for white matter dysplasia in preterm infants. Methods A total of 100 preterm infants were selected as the study subjects, all of whom received aEEG within 6 hours after birth, cMRI within 3 days after birth, and Neonatal Behavioral Neurological Assessment (NBNA) at 42 weeks of corrected gestational age. According to the NBNA score, preterm infants were divided into the normal group or the abnormal group. The aEEG score and cMRI indexes [interhemispheric distance (IHD) and biparietal diameter (BPW)] were compared between the two groups, and receiver operating characteristic (ROC) curves were used to evaluate the predictive value of aEEG score combined with cMRI indexes for white matter dysplasia in preterm infants. Results Of the 100 preterm infants, 45 cases were in the normal group (NBNA score ≥ 37 points), 55 cases were in the abnormal group (NBNA score < 37 points), and there was no statistically significant difference in the baseline data between the two groups (all P>0.05). Compared with the normal group, the abnormal group had a lower aEEG score, a greater IHD, and a shorter BPW (all P<0.05). The ROC curve analysis showed that the sensitivity and specificity of the combination of aEEG score and cMRI indexes (IHD and BPW) were 90.31% and 80.72%, respectively, in predicting white matter dysplasia in preterm infants. Conclusion aEEG and cMRI can reflect the development of white matter in preterm infants, and their combination shows great efficacy in predicting white matter dysplasia in preterm infants.

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