内科

目的探讨药学干预在呼吸内科中的应用和对抗菌药物使用情况的影响。方法以开展药学干预的时间为节点，2020年1～12月（开展药学干预前）的50例住院患者作为对照组，2021年1～12月（开展药学干预后）的50例住院患者作为研究组。对照组给予常规抗菌药物治疗，研究组在对照组的基础上增加药学干预。比较两组抗菌药物联用情况、抗菌药物使用不合理情况、抗菌药物用药频度（DDDs）和药物利用指数（DUI）。结果研究组单一用药、二联用药、三联及以上用药情况均优于对照组，抗菌药物使用不合理比率、抗菌药物DDDs和DUI均低于对照组（均P<0.05）。结论药学干预可合理指导呼吸内科患者的抗菌药物治疗，改善抗菌药物使用不合理情况。

Objective To explore the application of pharmaceutical intervention in Department of Respiratory Medicine and its impact on the use of antimicrobials. Methods According to the time of the pharmaceutical intervention, 50 inpatients from January to December 2020 (before the pharmaceutical intervention) were assigned as the control group, and 50 inpatients from January to December 2021 (after the pharmaceutical intervention) were assigned as the study group. The control group was treated with conventional antimicrobials, based on which the study group was given pharmaceutical intervention additionally. The combination, irrational use, defined daily dose system (DDDs), and drug utilization index (DUI) of antimicrobials were compared between the two groups. Results The antimobial treatment, with one, two, three, and more antimicrobials, in the study group was better than that in the control group, the proportion of irrational antimicrobial use and the antimicrobial DDDs and DUI in the stuoly group were lower than those in the control group (all P<0.05). Conclusion Pharmaceutical intervention can rationally guide the antimicrobial treatment and optimize the irrational use of antimicrobials for inpatients in the Department of Respiratory Medicine.

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