ObjectiveTo explore the efficacy of acupoint application of traditional Chinese medicine combined with budesonide in the treatment of mycoplasmal pneumonia in children and its effects on the inflammation level and immune function. MethodsA total of 124 children with mycoplasmal pneumonia were selected as research objects and randomly divided into a control group or an observation group, with 62 cases in each group. The control group was treated with nebulized budesonide inhalation, based on which the observation group was treated with acupoint application of traditional Chinese medicine, and both groups were treated continuously for 2 weeks. The clinical efficacy, inflammatory indicators levels and immune function before and after treatment, and incidence of adverse reactions during treatment were compared between the two groups. ResultsAfter 2 weeks of treatment, the total effective rate of treatment in the observation group was higher than that in the control group (96.77% vs. 83.87%), and the difference was statistically significant (P＜0.05); the relative expression levels of tumor necrosis factor receptor-associated factor-6 and nuclear factor kappa-B mRNAs, as well as the serum levels of CD8+, interferon(IFN)-γ, and interleukin(IL)-4, decreased in the two groups, and those in the observation group were lower than those in the control group (all P＜0.05); the serum CD3+, CD4+, immunoglobulin(Ig)A, IgG, IgM levels; CD4+/CD8+; and IFN-γ/IL-4 increased in both groups; those in the observation group were higher than those in the control group (all P＜0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups during treatment (P＞0.05). ConclusionThe treatment of acupoint application of traditional Chinese medicine combined with budesonide can regulate the cellular and humoral immune function of children with mycoplasmal pneumonia, inhibit inflammatory response, improve clinical symptoms, and enhance clinical efficacy.

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