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当前位置：首页 / 心肌梗死患者CD4+CD25+Foxp3+ T细胞检测及意义▲

论著 | 更新时间：2016-02-15

心肌梗死患者CD4+CD25+Foxp3+ T细胞检测及意义▲

Significance of the change of CD4+CD25+ Foxp3+ regulation T cells in patients with myocardial infarction

贺慧娟，吴海*，廖钦晨，陈世德，闭奇

内科 201001期页码：1-3

作者机构：广西医科大学第一附属医院心血管内科，南宁市530021

基金信息：▲广西自然科学基金资助（0640108）；*通讯作者

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目的探讨心肌梗死患者外周血CD4+CD25+ Foxp3+ T细胞的水平及意义。方法采用流式细胞分析法，检测20例急性心肌梗死患者（AMI组）、21例陈旧性心肌梗死患者（OMI组）和36例健康体检者（对照组）外周血CD4+CD25+ Foxp3+ T细胞水平。结果AMI组、OMI组的CD4+CD25+T细胞 /CD4+T细胞比例分别为（7.20±1.96）%和（7.55±1.77）%均低于对照组的（8.81±1.50）%（P＜0.05）；CD4+CD25+ Foxp3+ T细胞/CD4+T细胞比例AMI组为（1.42±0.38）%和OMI组为（1.46±0.55）%均比对照组（1.75±0.58）%低（P＜0.05）。结论CD4+CD25+调节性T细胞比例降低可能打破了外周免疫耐受，参与了心肌梗死患者动脉粥样硬化的发生发展。

ObjectiveTo explore the significance of the change of CD4+CD25+ Foxp3+ regulation T cells in peripheral blood of patients with myocardial infarction.MethodsThe proportion of CD4+CD25+ Foxp3+ T cells were detected in 20 patients with acute myocardial infarction (AMI group)， 21 patients with old myocardial infarction (OMI group) and 36 healthy individuals (control group) by flow cytometry.ResultsCD4+CD25+T cells /CD4+ T cells in both AMI group(7.06±2.15)%and OMI group (7.55±1.77)%were significantly lower than in control group(8.81±1.50)%(P＜0.05). Moreover CD4+CD25+ Foxp3+ cells /CD4+T cells in both AMI group(1.43±0.48)%and OMI group(1.46±0.55)%were significantly lower than in control group(1.75±0.58)%(P＜0.05).ConclusionReduction of CD4+CD25+ regulation T cells may lead to the breakdown of peripheral autoimmune tolerance and participate in the progression of atherosclerosis and myocardial infarction.

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