ObjectiveTo compare clinical efficacy and safety between ziprasidone and perphenazine in the treatment of elderly schizophrenia.Methods72 cases of elderly patients with schizophrenia were randomly divided into ziprasidone group and perphenazine group for 8 weeks.Positive and Negative Syndrome Scale (PANSS) was used to assess the efficacy,side effects scale (TESS) was used to assess adverse reactions.ResultsAfter 8 weeks,effective rate of ziprasidone group was 69.44%,with a total effective rate was 88.89%;perphenazine group were 63.89% and 86.11%,respectively,no statistical difference in therapeutic effect (P＞0.05).However,compared to perphenazine group,adverse reactions of ziprasidone group were much smaller and lighter.ConclusionZiprasidone in treatment of elderly schizophrenia is of good efficacy and relatively small adverse reactions.

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