Objective To investigate the clinical effect of simvastatin combined with N-acetylcysteine in the treatment of patients with bronchial asthma. Methods A total of 61 patients with bronchial asthma were selected as research subjects and randomly divided into the control group (n=31) or the observation group (n=30). The control group was treated conventionally, based on which the observation group was treated with a combination of simvastatin and N-acetylcysteine additionally, and both groups were treated for 6 weeks. The clinical efficacy, lung function and inflammatory factors levels before and after treatment, and the incidence of adverse reactions during treatment were compared between the two groups. Results After 6 weeks of treatment, the total effective rate of treatment of the observation group was higher than that of the control group; the tested peak expiratory flow over expected, forced vital capacity, and forced expiratory volume in 1 second were increased in both groups, and the above indexes in the observation group were higher than those in the control group; the serum levels of interleukin-6, interleukin-17, and tumor necrosis factor-α in the two groups were decreased, and the above indexes in the observation group were lower than those in the control group (all P<0.05). There was no statistically significant difference in the incidence of adverse reactions during treatment between the two groups (P>0.05). Conclusion Simvastatin combined with N-acetylcysteine has a good clinical effect in the treatment of patients with bronchial asthma, which can effectively improve their lung function, reduce inflammatory factors levels, alleviate airway inflammation, and the adverse reactions are mild.

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