内科

目的探讨急性冠脉综合征（ACS）患者血清总胆固醇（TC）、总胆汁酸（TBA）及总胆红素（TBIL）的变化及临床意义。方法选取住院治疗的100例ACS患者为观察组，其中稳定型心绞痛（SA）39例，不稳定型心绞痛（UA）38例，急性心肌梗死（AMI）23例。同期健康体检者100例为对照组，检测两组血清总胆固醇（TC）、总胆汁酸（TBA）及总胆红素（TBIL）的水平，并做相关统计学分析。结果观察组的TC及TBA水平高于对照组，差异有统计学意义（P＜0.05）；且观察组的TC及TBA水平由SA、UA到AMI依次升高，差异有统计学意义（P＜0.05）；观察组的TBIL水平低于对照组，差异有统计学意义（P＜0.05）；观察组的TBIL水平由SA、UA到AMI依次减低，差异有统计学意义（P＜0.05）。结论TC、TBA及TBIL联合检测对ACS的诊断及病情发展评价有重要的临床意义。

ObjectiveTo study the changes and clinical significance of serum total cholesterol (TC),total bile acid (TBA) and total bilirubin (TBIL) in patients with acute coronary syndrome (ACS).MethodsA total of 100 ACS patients were enrolled as obseroation group,in which 39 patients with stable angina (SA) and 38 patients with unstable angina (UA) as well as 23 patients with acute myocardial infarction (AMI) were studied.100 healthy individuals were selected as control group.Then,their TC,TBA and TBIL level were detected.The collected data were dealt with statistical analysis.ResultsThe TC and TBA levels of obseroation group were significantly increased compared with the control group,the difference was statistically significant (P＜0.05).And the levels of TC and TBA of obseroation group in turn increased significantly by the SA,UA to AMI (P＜0.05).While the TBIL level of obseroation group was lower than the control group,the difference was statistically significant (P＜0.05).And the TBIL level of obseroation group was reduced in turn from SA,UA to AMI,the difference was statistically significant (P＜0.05).ConclusionThe combined detection of TC,TBA and TBIL has important clinical significance to diagnose,treat and observe ACS.

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