内科

目的观察来氟米特联合泼尼松治疗狼疮性肾炎的疗效。方法将68例狼疮性肾炎患者随机分为观察组对照组各34例，观察组接受来氟米特联合泼尼松治疗，对照组接受环磷酰胺联合泼尼松治疗，观察治疗后2周、4周、8周、12周、18周、24周、48周相关临床指标变化与不良反应。结果治疗48周后，两组24 h尿蛋白定量、SCr、抗dS-DNA抗体滴度均较治疗前明显降低，ALB、C3较治疗前明显升高，差异有统计学意义，但观察组效果好于对照组，差异有统计学意义。两组总有效率比较，差异无统计学意义（P＞0.05）。观察组不良反应发生率低于对照组，差异有统计学意义（P＜0.05）。结论来氟米特联合泼尼松治疗狼疮性肾炎的效果与环磷酰胺联合泼尼松的治疗效果相似，但副反应较轻。

ObjectiveTo observe the effectiveness of leflunomide combined with prednisone in the treatment of lupus nephritis.Methods68 patients with lupus nephritis were randomly divided into two groups (34 patients per group), the observation group was received leflunomide combined with prednisone, while the control group was received cyclophosphamide combined with prednisone. Follow up the 2、4、8、12、18、24、48 weeks after treatments and observe clinical indexes and adverse reactions.Results24h urinary protein, SCr and anti-dS DNA antibody titer were significantly decreased after 48 weeks of treatments, ALB and C3 were significantly increased. No significant difference between the two groups was observed (P＞0.05). The adverse reaction rate in observation group was higher than in control group, the difference was statistically significant (P＜0.05).ConclusionThe effectiveness of leflunomide combined with prednisone in the treatment of lupus nephritis parallels the effectiveness of cyclophosphamide combined with prednisone,with less side reactions and in effect in treating lupus nephritis.

ref