ObjectiveTo analyze the value of Cys C and microalbuminuria in diagnosis of early kidney damage in children with allergic purpura. Methods30 cases of early kidney damage in children with allergic purpura were treated as the observation group, and 30 cases children with healthy physical examination were selected as the control group, the microalbuminuria series were measured by immune nephelometry assay, and the level of serum Cys C was measured by liquid phase transmission turbidity, while the serum creatinine was detected by Jaffe′s power law, the test data were statistically analyzed. ResultsThe six urine indexes in observation group were significantly higher than those in control group (P＜0.05); the ROC curve area of ALBU/UCR, NAG/UCR, ɑ1-MU/UCR, IGGU/UCR, Cys C,TRF for early kidney damage in children with allergic purpura were 0.838,0.791,0.818,0.822,0.651,0.871, respectively, and the sensitivity were 66.7%, 66.7%, 93.3 %, 80.0%, 53.3%, 80.0%, respectively, and specificity were 93.3%, 86.6%, 66.7%, 86.7%, 73.4%, 80.0%, respectively; 25 cases (83.33%) in observation group had one or more indicators abnormal in six indicators of hematuria, the exception rate was significantly higher than conventional detection of abnormal renal function (0%) (P＜0.05). The level of microalbuminuria series were positively correlated with Cys C. ConclusionsThe combined microalbuminuria series and serum Cys C tests diplay high sensitivity in the diagnosis of early kidney damage in children with allergic purpura, which may contribute to the early diagnosis and treatment,and the effect is significant.

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