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当前位置：首页 / 白介素-17和抗-CCP抗体联合检测对类风湿关节炎活动度及骨侵蚀的预测价值▲

论著 | 更新时间：2016-02-18

白介素-17和抗-CCP抗体联合检测对类风湿关节炎活动度及骨侵蚀的预测价值▲

The Predictive Value of combinational detection of IL-17 and Anti-CCP in Rheumatoid Arthritis activity and bone erosion

王小超，陆翔*，李天资，陆玉敏，黄俊利，陶丽菊

内科 201005期页码：455-457

作者机构：右江民族医学院附属医院血液风湿科，广西百色市533000

基金信息：▲基金项目：广西教育厅立项项目（200701LX111） *通讯作者

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目的探讨联合检测白介素（IL）-17和抗环瓜氨酸肽（CCP）抗体对类风湿关节炎（RA）活动度及骨侵蚀的预测价值。方法收集80例RA患者和30例健康体检者（健康对照组）的血液样本，应用ELISA检测血清IL-17和抗-CCP抗体，结合双手X线分期，分析RA患者与健康对照者之间，及RA早期与非早期，RA活动期与缓解期，RA骨侵蚀与非骨侵蚀之间IL-17、抗-CCP抗体的差异。结果（1）RA患者的IL-17、抗-CCP抗体高于健康对照者，差异有统计学意义（P＜0.05）；（2）早期RA组与非早期RA组之间比较，IL-17、抗CCP抗体水平差异无统计学意义（P＞0.05），RA活动组高于缓解组、骨侵蚀组高于非骨侵蚀组，差异有统计学意义（P＜0.05）。结论IL-17、抗-CCP抗体联合检测对类风湿关节炎活动度及骨侵蚀具有预测价值。

ObjectiveTo investigate the clinical significance of combinational detection of IL-17 and anti-CCP in Rheumatoid Arthritis(RA) activity and bone erosion.MethodsIL-17,anti-CCP of 80 cases of RA patients and 30 cases of health control detected by ELISA,Combined with hand x-ray films,were compared between early RA group and non-early RA group,activity group and inactivity group,bone erosion group and non-bone erosion group.ResultsIL-17 and anti-CCP are both elevated significantly in RA patients compared to the health control;IL-17,anti-CCP in the early RA group and the non-early RA group had no significant difference(P＞0.05);there was significant difference(P＜0.05) between activity group and non-activity group,bone erosion group and non-bone erosion group.ConclusionIt’s valuable to predict the activity and bone erosion of RA,using Combinational detection of IL-17,anti-CCP.

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