内科

目的探讨高效抗逆转录病毒治疗（Highly active antiretroviral therapy，HAART）对AIDS/TB和AIDS/TB/HCV患者CD4+T细胞及ALT的影响，以提高对AIDS/TB/HCV合并感染患者的治疗水平。方法对43例AIDS/TB，16例AIDS/TB/HCV患者实施HAART方案，分析比较两组治疗前后的CD4+T细胞数及ALT水平的变化情况。结果经1年的HAART方案治疗后两组CD4+T细胞均增加，与治疗前比较差异有统计学意义（P＜0.05），但两组比较差异无统计学意义（P＞0.05）；治疗后两组ALT水平均增高，AIDS/TB/HCV组增加幅度大于AIDS/TB组，差异有统计学意义（P＜0.05）。结论抗病毒治疗对AIDS/TB和AIDS/TB/HCV组都有效，两组间的治疗效果差别不大；抗病毒治疗对AIDS/TB/HCV患者肝功能损害大，但在使用护肝药物后近期是能耐受，远期治疗效果和对肝功能的影响需进一步观察。

ObjectiveTo explore the influence of HAART on CD4+T cells and ALT levels of AIDS/TB and AIDS/TB/HCV infected patients,aimed to improve the therapeutic technology.MethodsHAART was carried out in 43 cases AIDS/TB and 16 cases AIDS/TB/HCV infected patients,then compared the changes of CD4+T cells and ALT levels before and after Treatment.ResultsAfter 1 year of HAART treatment,CD4+T cells had increased significantly(P＜0.05) in both groups compared with pretreatment,but the effect between the 2 groups hadn′t significant difference(P＞0.05);ALT of the two infected groups were increased,the increase was more obvious in AIDS/TB/HCV patients then AIDS/TB patients(P＜0.05);ConclusionHAART are effective in both groups,but there hadn’t significant difference between AIDS/TB/HCV and AIDS/TB patients;HAART created more severe liver damage in AIDS/TB/HCV patients than AIDS/TB,but patients can endure a short-term liver damage under the protect of hepatoprotective,further observation are still needed to identify long-term therapeutic effect and impact on liver function of HAART.

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