内科

目的观察多西他赛（DOC）联合5-氟尿嘧啶（5-Fu）和亚叶酸钙（CF）（简称DF方案）治疗老年晚期胃癌的临床疗效及不良反应。方法对30例老年晚期胃癌患者，采用DOC 75 mg/m2，静脉滴注，第1天；CF 200 mg/m2静脉滴注，第1天，2 h后5-Fu 500 mg 静脉推注，随后5-Fu 2 500 mg/m2持续48 h化疗泵静脉内注入，21天为1个周期，2周期后评价疗效。结果30例患者均可评价疗效，其中完全缓解3例，部分缓解13例，稳定9例，进展5例，有效率53.3%，中位疾病进展时间为5.4个月，中位生存期10.8个月。不良反应主要是骨髓抑制、胃肠道反应和手足综合征，均为可逆性，无治疗相关性死亡。结论DF方案治疗老年晚期胃癌疗效好，不良反应轻，患者耐受性好，值得临床推广。

ObjectiveTo observe the clinical efficacy and adverse reactions of the combination of docetaxel (DOC),Fluorouracil (5-Fu) and Calcium Folinate (CF) (DF project for short)in the treatment of elderly patients with advanced gastric cancer.Methods30 patients with advanced gastric cancer were treated with DOC 75 mg/m2,CF 200 mg/m2 iv the first day,and 5-Fu 500mg iv after 2 hours,then injected 5-Fu 2500 mg/m2 through a vena pump continuously for 48 hours;repeated every 3 weeks (as a therapeutic cycle),The effect was evaluated after two cycles.Resultsclinical response was evaluated in 30 patients.3 patients completely response,13 patients partially response,9 at the stable stage and 5 progression were observed with an overall response rate of 53.3%,The median time of progression was 5.4 months and median survival time were 10.8 months.The most common toxicities were bone marrow suppression,vomiting and Hand-foot-syndrome.All of them are reversible.There was no treatment related death.ConclusionCombining DOC with 5-Fu and CF is an effective and better tolerated alternative treatment on elderly patients with advanced gastric cancer and yields promising activity.

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