内科

目的观察羟乙基淀粉130/0.4氯化钠注射液（商品名：亿汶）在重症急性胰腺炎（SAP）患者中应用的有效性及安全性。方法48例未手术的SAP患者，用随机方法分成治疗组和对照组，各24例。两组均禁食、胃肠减压、抑酸、抑酶、抑制胰腺分泌、抗炎、维持水盐电解质平衡及营养支持治疗，治疗组羟乙基淀粉130/0.4，500 ml/d，静脉滴注疗程7 d；对照组乳酸钠林格氏液500 ml/d，静脉滴注疗程7 d。观察两组血液流变学、凝血功能的变化。结果治疗7 d后，治疗组血液流变学及凝血功能改善程度好于对照组，差异有统计学意义（P＜0.05）。结论羟乙基淀粉130/0.4可能通过改善微循环从而促进重症急性胰腺炎的转归。

ObjectiveTo observe the efficacy and safety of hydroxyethyl starch 130/0.4 in severe acute pancreatitis (SAP) patients.Methods48 SAP patients(without surgical operation) were randomized into treatment group and control group,24 cases respectively.Both groups were conducted to fasting,gastrointestinal decompression,suppression of acid and enzyme,pancreatic secretion,anti-inflammatory,maintain water quality in the salt solution balance and nutrition support.Hydroxyethyl starch 130/0.4 was used in treatment group,500ml/d intravenous drip,7 days as a therapy circle;sodium Lactated Ringer′s solution was used in control group,500ml/d intravenous drip,7 days as a therapy circle.Then observe the change of blood rheology,coagulation function.ResultsAfter 7 days of treatment,the changes of blood rheology and blood coagulation function were different significantly(P＜0.05), the improvement of the treatment group are better than control group.ConclusionIt′s likely that hydroxyethyl starch 130/0.4 can improve microcirculation so as to improve the outcome of severe acute pancreatitis.

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