ObjectiveTo investigate the relationship between cystatin C and coronary artery disease in patients with diabetic mellitus. MethodsA total of 226 patients with diabetic mellitus were selected and divided into complicated with CHD group (144 cases) and without CHD group (82 cases) according to the results of coronary angiography, and complicated with CHD group were divided into single branch lesion group (37 cases), double vessel lesion group(41 cases) and multi vessel disease group (66 cases) according to the number of diseased vessels, and the severity of coronary artery stenosis was evaluated by Gensini score;without CHD group was divided into coronary artery smooth group (42 cases) and coronary atherosclerosis group(40 cases). The general clinical data and biochemical indicators of each group were detected and analysed. ResultsThe proportion of male and the level of Cys-C in complicated with CHD group were significant higher than those in without CHD group, the level of Cys-C is increased with the increase of the number of diseased coronary artery, and was positively correlated with Gensini score (P＜0.05) .Logistic regression analysis results show that male and the levels of serum Cys-C were the risk factors of DM complicated with CHD. ConclusionsThe levels of serum Cys-C and male are the risk factor of DM complicated with CHD, and can predict the risk of cardiovascular disease in patients with DM.

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