ObjectiveTo investigate the clinical effect of probucol combined with atorvastatin in treating carotid atherosclerosis plaque. MethodsA total of 80 patients with cerebral infarction complicated with carotid atherosclerosis plaque were selected and randomly divided into observation group and control group,with 40 cases in each group. All patients received conventional treatment including antihypertensive, hypoglycemic, anti platelet aggregation etc, and control group was given atorvastatin on the basis of conventional treatment, while the observation group received probucol and atorvastatin on the basis of conventional treatment, the course of treatment was 6 months.Blood lipid,IMT, the length and thickness of the plaques between two groups were compared before and after treatment. ResultsThe total effective rate of the observation group (90%) was significantly higher than that of control group (70%, P＜0.05). After treatment, IMT, the length and thickness of the plaques, the level of TC,TG, LDL-C in two groups were decreased significantly as compared with those before treatment, and the level of HDL-C was increased significantly as compared with that before treatment, and IMT, the length and thickness of the plaques, the level of TC,TG, LDL-C in observation group were significantly lower than those of control group, while the level of HDL-C was significantly higher than that of control group(P＜0.05). ConclusionsProbucol combined with atorvastatin in treating carotid atherosclerosis plaque can increase therapeutic effect, reduced plaque, which is worth popularizing in clinical practice.

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