目的探讨血栓通注射液联合低分子肝素治疗对老年高龄急性冠脉综合征患者介入治疗后炎症因子及疗效的影响。方法将90例老年高龄急性冠脉综合征介入治疗术后患者随机分为观察组和对照组,每组45例。对照组患者采用常规治疗,观察组在常规治疗的基础上,加用血栓通静脉注射及低分子肝素皮下注射治疗,对比两组患者的治疗效果以及治疗前后炎症因子水平的变化。结果治疗后两组患者炎症因子水平均明显降低,观察组患者C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平低于对照组,差异具有统计学意义(P<0.01);观察组患者治疗总有效率为93.33%,对照组为73.33%,两组比较差异有统计学意义(P=0.024);观察组患者不良事件发生率(2.22%)低于对照组(17.78%),差异具有统计学意义(P=0.035)。结论对老年高龄急性冠脉综合征行介入治疗术后患者采用血栓通联合低分子肝素治疗可以显著降低炎症因子水平,提高疗效,降低不良事件发生率。
ObjectiveTo explore the effect of thrombus clear combined with low molecular heparin on inflammatory factors and efficacy in elderly patients with acute coronary syndrome after percutaneous coronary intervention treatment. MethodsA total of 90 elderly patients with acute coronary syndrome who underwent percutaneous coronary intervention treatment were randomly divided into observation group and control group, with 45 cases in each group. The control group were treated with conventional therapy, while the observation group received thrombus clear and low molecular heparin on the basis of control group, inflammatory factors between two groups were compared before and after treatment, and the efficacy of the two groups was also observed. ResultsAfter treatment, the level of inflammatory factors in two groups were decreased significantly as compared with that before treatment, and the levels of CRP, TNF- α and IL-6 in the observation group were significantly lower than those in control group (P<0.01). The total effective rate was 93.33% in the observation group and 73.33% in the control group, the difference between two groups was significant(P=0.024).The rate of adverse effect in the observation group (2.22%) was significantly lower than that in the control group (17.78%,P=0.035). ConclusionsThrombus clear combined with low molecular heparin in treating elderly patients with acute coronary syndrome after percutaneous coronary intervention treatment can decrease the levels of inflammatory factors, improve efficiency and reduce the incidence of adverse events.