ObjectiveTo investigate the effects of insulin pump on the the level of IL-6 and TNF-α and clinical efficacy in patients with newly diagnosed type 2 diabetes. MethodsA total of 138 patients with newly diagnosed type 2 diabetes were randomly divided into insulin pump group (group A) and multiple subcutaneous infusion group (group B), with 69 cases in each group, the course of treatment was 14 days. The level of IL-6, TNF-α, fasting blood glucose,insulin at 2 hours after meal,bedtime blood glucose,time of reaching target of glucose,insulin dosage,the incidence rate of hypoglycemia,insulin resistance(HOMA IR) and insulin secretion index (HOME-beta) between two groups were compared before and after treatment. ResultsAfter treatment, the levels of insulin at 2 hours after meal in two groups was well controlled, and the 2hPG in group A was significantly better than that in group B (P＜0.05); the level of IL-6 and TNF-α and HOMA-IR in two groups were decreased significantly as compared with those before treatment, while HOME-β was increased significantly as compared with that before treatment (P＜0.05);time of reaching target of glucose,insulin dosage,the incidence rate of hypoglycemia in group A were significantly lower than those in group B, but the treatment cost of group A was significantly higher than that of group B(P＜0.05). ConclusionsCompare with multiple subcutaneous infusion, insulin pump can obviously improve β-cell function, reduce insulin resistance and the level of inflammatory factors in patients with type 2 diabetes and have better clinical efficacy.

无