ObjectiveTo observe the clinical effect of kallidinogenase combined with lipoic acid in treatment of diabetic retinopathy (DR). MethodsA total of 112 patients with DR were randomly divided into observation group and control group, with 56 cases in each. Both groups were controled blood sugar in the normal range with insulin, besides, the control group was given oral kallidinogenase with the dose of 240U per time (three times a day) , while the observation group was given oral to lipoic acid with the dose of 0.6g per time (once a day) on the basis of the treatment of control group. Both groups were treated for 12 weeks, and the therapeutic effects were evaluated, changes of blood lipid microcirculation and hemorheology were observed before and after treatment. ResultsThe effective rate of observation group (82.14%) was significantly higher than that of control group (64.29%, P＜0.05),and the curative effect of the observation group was superior to that of control group(P＜0.05); compared with before treatment, the blood lipid and hemorheology in the two groups were improved significantly after treatment(P＜0.05), and these indices in the observation group was superior to control group(P＜0.05). No evident toxic effects was found in two groups during the course of therapy. ConclusionsThe clinical effect of kallidinogenase combined with lipoic acid in treatment of diabetic retinopathy is significant; lipoic acid may be can lower the level of lipid, and improve blood lipid microcirculation and hemorheology of DR while combined with kallidinogenase.

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