ObjectiveTo investigate the effects of thymopentin on macrophages phagocytosis of enterocoelia in rats. MethodsA total of 13 Wistar rats were injected intraperitoneal with 5% starch solution to generating macrophages.Then after 72 hours of injection, enterocoelia macrophages were lavaged and fetched. Staphylococcus aureus suspension was divided into two groups, the experimental group was mixed with 5 μL TP-5(effective concentration:1mg/mL),while the control group was mixed with the same volume of saline, and 13 subgroups were set in each group, 450 μL macrophage suspension was added to each subgroup after 30 minutes of incubation. Cell smear was conformed after 40 minutes of incubation in vitro, Giemsa staining was used to detect the cell smear and cellular morphology was observed on the glass slides, the phagocytosis rate and phagocytosis number were calculated. ResultsThe number of macrophages which phagocytosised bacteria, the total number of bacteria which phagocytosised by macrophages, the average rate of phagocytosis and the average of phagocytosis number in experimental group were significantly more or higher than those of the control group (P＜0.01). ConclusionsThymopentin may be can change the structure of Staphylococcus aureus and (or) enhance the macrophage cytotoxicity,which could improve the function of macrophages to swallow Staphylococcus aureus.

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