内科

目的探讨血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性和α-内收蛋白（ADD）基因Gly460Trp多态性与广西壮族盐敏感高血压患病的关系。方法选择广西壮族高血压患者100例为研究对象，根据冷加压试验检测结果，将患者分为盐敏感高血压患者（盐敏感组）与盐不敏感高血压患者（盐不敏感组），每组50例。应用多聚合酶链反应（PCR）和限制性片段长度多态性（PCR-RFLP）技术检测两组患者ACE基因插入/缺失（I/D）和ADD基因的多态性，比较两组患者ACE基因型和ADD基因型的分布频率（%）。结果盐敏感与盐不敏感高血压患者盐摄入量、体质指数、HDL-C、LDL-C水平比较差异无统计学意义（P＞0.05）；盐敏感组患者血压（SBP/DPB）、基础心率、TC、TG水平高于盐不敏感组，差异有统计学意义（P＜0.05）。盐敏感与盐不敏感高血压患者ACE基因型和ADD基因型的分布频率（%）比较，差异无统计学意义（P＞0.05）。结论ACE基因I/D多态性和ADD基因Gly460Trp多态性与广西壮族盐敏感高血压患者的患病无显著关联，可能不是广西壮族盐敏感高血压患病的易感因素。

ObjectiveTo investigate the association between angiotensin converting enzyme （ACE） insertion/deletion （I/D） polymorphisms, a-adducin(ADD) gene and salt-sensitive hypertension of Zhuang Nationality. MethodsA total of 100 Zhuang nationality inpatients with hypertension were divided into salt-sensitive group and non-sah-sensitive group according to cold pressure test results, with 50 cases in each group.The polymorphisms of angiotensin converting enzyme （ACE） insertion/deletion （I/D） and ADD gene were detected by PCR and PCR-RFLP. The genotypic distribution frequency of ACE and ADD gene were compared between the two groups. ResultsNo significant difference of salt intake, BMI, HDL-C, LDL-C was found between the two groups (P＞0.05), but BP (SBP/DPB), basic heart rate, the level of TC and TG in salt-sensitive group were significantly higher than those in non-sah-sensitive group (P＜0.05). No significant difference of genotypic distribution frequency of ACE and ADD gene was found between the two groups (P＞0.05). ConclusionsThere is no remarkable correlation between I/D polymorphisms of ACE gene,460G/T polymorphisms of ADD gene and salt-sensitive hypertension patients of Zhuang Nationality in Guangxi, with may be not the susceptible factor of salt sensitive hypertension of Zhuang nationality.