ObjectiveTo study the influence of pravastatin on serum lipids, high sensitivity C reactive protein and platelet activation in patients with diabetes mellitus complicated with hyperlipidemia, and provide basis for clinical diagnosis and treatment. MethodsA total of 150 patients with diabetes mellitus complicated with hyperlipidemia were selected in our hospital from January 2015 to January 2016, and were randomly divided into study group and control group, with 75 cases in each group. The control group was given simvastatin, while the study group was given pravastatin, hs CRP, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), platelet membrane glycoprotein CD62P and CD63 were compared between two groups before and after treatment. ResultsAfter treatment, the levels of hs-CRP, TC, TG, LDL-C, platelet membrane glycoprotein CD62p and CD63 in the two groups decreased significantly while the levels of HDL-C increased significantly compared with those before treatment(P＜0.05), and the levels of hs-CRP in the study group was significantly lower than that in the control group, while the levels of HDL-C was significantly higher than that in the control group(P＜0.05), no statistical significance was found between two groups in the levels of TC, TG, LDL-C, platelet membrane glycoprotein CD62p and CD63(P＞0.05). ConclusionsPravastatin and simvastatin in the treatment of diabetes mellitus complicated with hyperlipidemia has good lipid-lowering effect, and can reduce the activity of platelet.

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