ObjectiveTo investigate the relationship between hyperhomocysteinemia and acute cerebral vascular accident in patients with carotid unstable plaque. MethodsThe clinical data of 300 patients with carotid unstable plaque were analyzed retrospectively, and the patients were divided into stroke group (218 cases) and non stroke group (82 cases) according to the occurrence of acute cerebrovascular events. The relationship between the levels of serum homocysteine and plaque thickness was analyzed; the proportion of gender, age, drinking, smoking, complicated with diabetes, high blood pressure and coronary heart disease (CHD) were compared between the two groups; the levels of blood pressure, FBG, 2h-PG, HbA1c and Hcy were also compared between the two groups; the levels of Hcy were compared among patients with different cognitive impairment in the stroke group. ResultsThe level of serum Hcy had positive correlation with plaque thickness in patients with unstable carotid plaque(r=0.317, P＜0.05). The levels of FBG, 2h-PG, HbA1c and serum Hcy in the stroke group were significantly higher than those in the non stroke group (P＜0.01), patients in the stroke group were significantly older than that in the non stroke group (P＜0.01). The level of serum Hcy in mild injury group was significantly lower than that in the moderate injury and severe injury group (P＜0.01), but there was no significant difference in the level of serum Hcy between moderate injury group and severe injury group (P＞0.05) . ConclusionsPatients with carotid unstable plaque in high level of serum Hcy might have higher incidences of acute cerebral vascular accident and neurological impairment.

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