ObjectiveTo compare the effect of low-dose sotalol and propafenone in the treatment of patients with arrhythmia and its impacts on QTd. MethodsA total of 104 patients with arrhythmia admitted to our hospital from September 2011 to February 2013 were selected and randomly divided into observation group and control group, with 52 cases in each group. The observation group was treated with low-dose sotalol while the control group received propafenone. The total effective rate, adverse effects and the changes of QTd were compared between the two groups. ResultsThe total effective rate in the observation group was 88.4% ,and the control group was 82.6%, there was no significant difference in total effective rate between two groups (P＞0.05). After treatment, maximum QT, minimum QT in the observation group were significantly longer than those before treatment, and the QTd was shorter than that before treatment (P＜0.05); maximum QT, minimum QT and QTd showed no improvemat after treatment in contrast with those before treatment in the control group (P＞0.05); the maximum QT, minimum QT in the observation group were significantly longer than those in the control group, and the QTd in the observation group was significantly shorter than that in the control group (P＜0.05). There was no significant difference in dizziness, headache, nausea, diarrhea, dyspnea, low blood pressure, heart failure between two groups (P＞0.05). ConclusionsThe effects of low-dose sotalol and propafenone in the treatment of patients with arrhythmia is similar, and there is no significant difference in the adverse reactions between the two, however, low-dose sotalol seems to be more effective than propafenone in QTd.

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