ObjectiveTo investigate the application value of procalcitonin (Procalcitonin, PCT) and adenosine deaminase (adenosine deaminase, ADA) in diagnosis of infantile meningitis. MethodsA total of 112 children with meningitis admitted to our hospital from January 2013 to January 2015 were selected as the study group, and 100 children with epilepsy in our hospital at the same period were selected as the control group, the levels of serum PCT and CSF-ADA were compared between two groups, and the indexes mention above were also compared among different type of infantile meningitis. ResultsThe levels of serum PCT and CSF-ADA in the study group were significantly higher higher than those in the control group (P＜0.05). The levels of serum PCT in the viral meningitis group, purulent meningitis group were significantly higher than those in the control group (P＜0.05), in the study group, the levels of serum PCT decreased in the following order: purulent meningitis, viral meningitis, tuberculous meningitis. The levels of CSF-ADA decreased in the following order: tuberculous meningitis, purulent meningitis, epilepsy, viral meningitis group, and the difference was statistically significant among the four groups (P＜0.05). The positive rate of PCT, CSF-ADA in the control group were both 0%; in the study group, the positive rate of PCT decreased in the following order: purulent meningitis (100.0%), viral meningitis (35.9%), tuberculous meningitis (0%); while the positive rate of CSF-ADA decreased in the following order: tuberculous meningitis (46.4%), purulent meningitis (20.0%),viral meningitis (0%). ConclusionsDetecting procalcitonin and adenosine deaminase is helpful for the diagnosis and differential diagnosis of meningitis in children, which is worthy of clinical application.

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