ObjectiveTo explore the value of urinary micro liver type fatty acid binding protein (L-FABP), kidney injury molecule (KIM-1) and serum neutrophil gelatinase associated lipocalin (NGAL) detection in diagnosing early kidney injury of patients with diabetic. MethodsEighty-six cases of patients with diabetes in our hospital from April 2013 to April 2015 were selected and forty-three healthy volunteers who had health examination in our hospital in the same period were also enrolled, and thirty-one cases of patients with diabetic who complicated with early kidney injury were noted as the group A, and the others were noted as the group B (55cases), then the healthy volunteers were noted as the group C. The levels of urinary micro L-FABP, KIM-1 and serum NGAL of all subjects were detected and compared among the three groups. ResultsThe levels of urinary micro L-FABP, KIM-1 and serum NGAL were decreased in the order of group A, group B and group C, and difference among the three groups was statistically significant (P＜0.05), there was significantly different between group A and group B, and there was also significantly different between group B and group C (P＜0.05); the levels of urinary micro L-FABP, KIM-1 and serum NGAL in diabetic patients with microalbuminuria were significantly lower than those of diabetic patients with macro albuminuria (P＜0.05). ConclusionsThe levels of urinary micro L-FABP, KIM-1 and serum NGAL are obviously increased in early kidney injury of patients with diabetic, which can provide reference for clinical diagnosis, treatment and prognosis of patients with diabetic combined with early kidney injury.

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