ObjectiveTo analyze the characteristics of gastrointestinal hormones in patients with irritable bowel syndrome accompanied with anxiety and depression, and investigate the correlation between gastrointestinal hormones and anxiety depression. MethodsA total of 150 patients with irritable bowel syndrome in our hospital from January 2012 to December 2014 were selected and divided into the anxiety depression group (59cases) and non-anxiety depression group (91cases) according to accompanied with anxiety and depression or not. The expression of cholecystokinin, motilin, somatostatin, vasoactive intestinal peptide and calcitonin peptide gene related peptide, and colonic motility index in different periods were compared between two groups. ResultsThe expression of somatostatin (SS), vasoactive intestinal peptide level(VIP) in anxiety depression group were significantly higher than those in the non-anxiety depression group (P＜0.05), and the expression of cholecystokinin (CCK), motilin (MTL) in anxiety depression group were significantly lower than those of non- anxiety depression group (P＜0.01); that was no significant difference of the expression of calcitonin gene related peptide was found between the two groups (P＞0.05).The dynamic index of fasting state in anxiety depression group was significantly higher than that of non-anxiety depression group, but dynamic index of 0.5h and 1 h after meal in anxiety depression group were significantly lower than those of the non-anxiety depression group (P＜0.01or P＜0.05). ConclusionsThe abnormal of cholecystokinin, motilin, somatostatin, vasoactive intestinal peptide can affect the gastrocolic reflex in patients with irritable bowel syndrome accompanied with anxiety and depression; there may be some intrinsic links between gastrointestinal hormones and anxiety depression,which needs further research.

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