ObjectiveTo explore the safety and efficacy of warfarin in the treatment of 80 years and older patients with atrial fibrillation, assess the feasibility of the HAS-BLED bleeding-risk-score system in guiding anticoagulation therapy in elderly patients. MethodsA total of 120 outpatient follow-up patients with atrial fibrillation in our hospital from January 2012 to January 2013 were enrolled and randomly divided into standard-intensity group and low-intensity group, with 60 cases in each group, and all patients were 80 years old or older.The standard-intensity group received warfarin for standard-intensity, while the low-intensity group received warfarin for low-intensity. After follow-up for one year, the incidences of major bleeding events and ischemic stroke were compared between two groups, and the HAS-BLED bleeding-risk-score system was used to evaluate the risk of hemorrhage. ResultsThat was no significant difference of incidence of ischemic stroke was found between the two groups (P＞0.05); the incidence of bleeding events in the standard-intensity group was significantly higher than that in the low-intensity group(P＜0.05).Among 120 cases of patients, the incidence rate of serious bleeding was 2.5% in patients who the score of HAS-BLED was 2 points or more, and no serious bleeding event was found in patients who the score of HAS-BLED was 1 points. ConclusionsLow-intensity and standard-intensity therapy with warfarin has the same effect in the treatment of 80 years and older patients with atrial fibrillation, but low-intensity can reduce the risk of hemorrhage. HAS-BLED bleeding-risk-score system can used to evaluate the risk of hemorrhage in elderly patients who receive anticoagulant therapy, correct and monitor the reversible bleeding-risk-factors can reduce the occurrence of bleeding events during anticoagulation therapy.

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