ObjectiveTo investigate the effect of shengmai acupoint injection on cardiac toxicity induced by bupivacaine infusion in rats. MethodsA total of 30 SD adult male rats were randomly divided into blank group（groupⅠ）, model group（group Ⅱ）, medicine group（group Ⅲ）, with 10 rats in each group. Normal saline 0.9% was pumped intravenously at a rate of 2 mg· kg-1 ·min-1 into the femoral vein in group Ⅰ, 0.5% bupivacaine was pumped intravenously at a rate of 2 mg· kg-1 ·min-1 into the femoral vein in group Ⅱ and group Ⅲ. Group Ⅰwas injected with saline in bilateral Neiguan-point; group Ⅱ and group Ⅲ were injected with normal saline and shengmai in bilateral Neiguan-point when arrhythmia occured. The heart rate（HR） before administration, the time of arrhythmia after received local anesthetics（as QRS extend to 90 ms） and cardiac arrest emergence were record, corresponding dosage of bupivacaine was calculated; Na+-K+-ATPase and lactate dehydrogenase of the cardiac muscle were measure. ResultsThe emergence of arrhythmia and cardiac arrest in group Ⅲ were significantly later than those in group Ⅱ, the corresponding dosage of bupivacaine in group Ⅲ was significantly larger than that in group Ⅱ(P＜0.05）; the level of Na+-K+-ATPase in myocardial of the group Ⅲ was significantly higher than that of group Ⅱ, and the level of lactic dehydrogenase in the group Ⅲ was significantly lower than that in the group Ⅱ(P＜0.05）. ConclusionsAcupoint injection with Shengmai can prevent and treat the cardiac toxicity induced by bupivacaine in rats, the mechanism may relate to enhancing myocardial tissue Na+-k+-ATPase activity and inhibiting lactic dehydrogenase activity.

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