ObjectiveTo explore the expression and clinical significance of serum pepsinogen and Helicobacter pylori （HP）IgG antibodies in patients with gastric cancer. MethodsA total of 68 patients with gastric cancer admitted to our hospital from March 2015 to July 2016 were selected as the gastric cancer group, 60 cases of healthy person who had health check-up in our hospital were selected as the control group, the levels of serum pepsinogen and Helicobacter pylori （HP）IgG antibodies were compared between the two groups. ResultsThe levels of PGI, PGII and PGI/PGII in the gastric cancer group were significantly higher than those in the control group (P＜0.05).The levels of serum PGI and PGII in the patients with high differentiation and low differentiation, with and without lymph node metastasis were significant differences. (P＜0.05); that was no significant difference of the levels of serum PGI and PGII was found among (between) the patients with difference location,or size of tumor, no statistical significance was found among the patients with different of depth of invasion, and TNM staging in the level of serum PGI and PGII (P＞0.05). Among 68 cases of patients with gastric cancer, HP positive was 39 cases and HP negative was 29 cases; the levels of PGI and PGII in HP positive patients were significantly higher than those in HP negative patients (P＜0.05); no statistical significance was found between HP positive and HP negative patients in PGI/PGII (P＞0.05). ConclusionsThe level of serum PG is significantly decreased in patients with gastric cancer after HP infection, the level of serum PGI and PGII, PGI/PGII might be the indicators to diagnose gastric cancer and predict the prognosis.

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