ObjectiveTo observe the effect and safety of compound wenzhong yuyang decoction combined with omeprazole in treatment of patients with duodenal ulcer of deficiency of yang and blood stasis. MethodsA total of 92 cases with duodenal ulcer of deficiency of yang and blood stasis patients were randomly divided into control group and study group, with 46 cases in each group. The control group were given omeprazole, while the study group received compound wenzhong yuyang decoction combined with omeprazole, the two groups were treated for 5 weeks. Chinese medicine symptoms score, clinical efficacy and helicobacter pylori eradication rate were compared between the two groups, adverse reaction during treatment and recurrence after six months of the two groups were also observed. ResultsCompared with that before treatment, Chinese medicine symptom score in the two groups was significantly decreased after treatment (P＜0.05); and the Chinese medicine symptom score in the study group was significantly lower than that of the control group (P＜0.05), the eradication rate of helicobacter pylori and total effective rate in the study group were significantly higher than those of the control group (P＜0.05); the incidence of adverse reactions in the study group was significantly lower than that of the control group (P＜0.05); after six months of treatment, the recurrence rate of the study group was significantly lower than that of the control group (P＜0.05). ConclusionsCompound wenzhong yuyang decoction combined with omeprazole in treatment of duodenal ulcer of deficiency of yang and blood stasis has a significant effect, and it is safety, which is worthy of clinical application.

无