内科

目的分析CD4 C868T单核苷酸多态性与广西人群对HIV-Ⅰ易感性的相关性。方法选取101例广西HIV-Ⅰ型感染者（HIV-Ⅰ感染组）和102例同期同地区的健康体检者（对照组），采用聚合酶链反应（PCR）及 DNA 测序法，检测CD4基因C868T位点（rs28919570C/T）多态性，对rs28919570C/T基因多态性和广西人群对HIV-Ⅰ的易感性进行相关性分析。以上统计均采用SPSS 16.0软件进行分析。结果rs28919570 C/T位点CC、CT、TT三种基因型在广西人群HIV-Ⅰ感染组和对照组中分布频率的差异无统计学意义（P＞0.05）。与CC基因型相比，CT及TT基因型和HIV-Ⅰ感染风险均无相关性（P＞0.05），且尚未发现rs28919570 C/T位点多态性与广西HIV-Ⅰ感染者性别差异有关。结论尚未发现rs28919570 C/T位点基因多态性与广西人群HIV-Ⅰ感染风险具有相关性。

ObjectiveTo explore the association between CD4 C868T single nucleotide polymorphisms and HIV-Ⅰ susceptibility in Guangxi population. Methods101 patients with HIV-Ⅰ(HIV-Ⅰinfection group) and 102 healthy persons in Guangxi were involved in this study. Polymerase chain reaction (PCR) and DNA sequencing were used to detect polymorphisms of CD4 C868T (rs28919570C/T). The correlation analysis of CD4 C868T single nucleotide polymorphisms and HIV-Ⅰwas conducted. SPSS 16.0 was used for statistical analysis. ResultsThree genotypes with CC, CT and TT were observed in rs28919570C/T, and no statistical significance in the frequency distribution was found between the two groups (P＞0.05). Comparing with CC genotype, either CT genotype or TT genotype was not associated with susceptibility to HIV-Ⅰinfection(P＞0.05). The three SNPs of rs28919570C/T were not associated with the gender of HIV-Ⅰinfected patients(P＞0.05). ConclusionsNo association between rs28919570C/T SNPs and HIV-Ⅰ susceptibility is found in Guangxi population.

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