内科

目的探讨血清铁蛋白（SF）与2型糖尿病（T2DM）的关系。方法以2型糖尿病患者220例为观察对象，按其SF浓度分别分为高SF组（150例，SF≥300 ng/mL）与正常SF组（70例，SF＜300 ng/mL），检测分析两组患者的身高、体重、血清铁蛋白（SF）、总胆固醇（TC）、三酯甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、糖化血红蛋白（HbA1c）、空腹血糖（FBG）、空腹胰岛素（FINS）、体重指数（BMI）、胰岛素抵抗指数（HOMR-IR）和胰岛β细胞功能（HOMA-β）。结果2型糖尿病患者的SF水平与BMI、FBG、FINS、HOMR-IR、HbA1c、TG、LDL-C均呈正相关（P均＜0.05），与HDL-C呈负相关（P＜0.05），与TC、LDL-C、HOMA-β无相关性（P＞0.05）；2型糖尿病高SF组患者FBG、HbA1c、FINS、HOMR-IR显著高于正常SF组患者（P＜0.05）。结论血清SF水平升高可能影响糖尿病患者的糖脂代谢；SF可能通过胰岛素抵抗来介导糖尿病的早期发展。

ObjectiveObjective To explore the relationship between serum ferritin and type 2 diabetes mellitus(T2DM). Methods220 hospitalized patients with T2DM were enrolled in this study.They were divided into high SF group(n=150;SF≥300 ng/mL) and normal SF group(n=150;SF＜300 mL) according to the SF concentration. The weights, serum ferritin, total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), glycosylated hemoglobin (HbAlc), Fasting Blood-glucose (FBG), fasting insulin (FINS), body mass index (BMI), insulin resistance index (HOMR-IR) and pancreatic β-cell function (HOMA-β) of all patients in both groups were measured and analyzed. ResultsThe level of SF was positively correlated with BMI, FBG, FINS, HOMR-IR, HbA1c, TG and LDL-C (P＜0.05 for all variables), but negatively correlated with HDL-C (P＜0.05).There was no correlation between SF and TC, LDL-C and HOMA-β (P＞0.05).The FBG, HbA1c, FINS and HOMR-IR in the high SF group were significantly higher than those in the normal SF group (P＜0.05). ConclusionsElevated SF may affect the metabolism of glucose and lipid in patients with diabetes; and SF may be involved in the early progress of process diabetes by insulin resistance.