目的探讨冠状动脉慢血流现象的临床特点及其与阻塞性睡眠呼吸暂停(OSA)的关系。方法选取冠脉造影显示冠状动脉慢血流现象、冠状动脉无明显狭窄病变的患者204例作为冠脉慢血流组,其中单支冠脉慢血流156例,多支冠脉慢血流48例;随机抽取同期冠脉造影显示冠状动脉血流正常的其他疾病住院治疗患者184例作为对照组,对比两组患者的睡眠呼吸暂停情况;根据呼吸暂停低通气指数(AHI)将冠脉慢血流组发生睡眠呼吸暂停的患者分为轻中度组和重度组,比较冠脉慢血流合并不同程度睡眠呼吸暂停患者的血小板平均体积(MPV)、校正的TIMI帧数(CTFC)。结果39.22%的冠脉慢血流患者发生OSA,高于对照组的21.74%(P<0.05)。多支冠状动脉慢血流组患者AHI显著高于单支冠脉慢血流组(P<0.05),夜间最低血氧饱和度(SPO2)低于单支冠脉慢血流组(P<0.05)。冠脉慢血流合并重度OSA组的MPV及 CTFC显著高于冠脉慢血流合并轻中度OSA组患者(P<0.05)。结论冠状动脉慢血流患者容易发生阻塞性睡眠呼吸暂停,且出现慢血流的冠状动脉支数越多,患者的阻塞性睡眠呼吸暂停症状越严重,冠脉慢血流合并阻塞性睡眠呼吸暂停患者病情可能与MPV及 CTFC有关。
ObjectiveTo explore the correlation between coronary slow flow phenomenon and obstructive sleep apnea(OSA). MethodsA total of 204 patients who underwent coronary arteriography which showed coronary slow flow phenomenon and had no coronary artery stenosis were selected as coronary slow flow group, including 156 cases of single coronary slow flow and 48 cases of multivessel coronary slow flow; 184 patients who had no coronary slow flow phenomenon were selected as control group, the rate of sleep apnea was compared between two groups; and the coronary slow flow group were divided into mild-moderate group and severe group according to apnea hypoventilation index (AHI), the mean platelet volume (MPV), CTFC were compared between two groups. ResultsThe rate of OSA in the coronary slow flow group (39.22%) was significantly higher than that of the control group (21.74%, P<0.05). The AHI in the multivessel coronary slow flow group was significantly higher than that in the single coronary slow flow group(P<0.05), the lowest nocturnal oxygen saturation in the multivessel coronary slow flow group was significantly lower than that in the single coronary slow flow group(P<0.05). The MPV and CTFC in the severe group were significantly higher than that in the mild-moderate group(P<0.05). ConclusionsPatients with coronary slow flow are liable to obstructive sleep apnea, the more the coronary count of slow flow, the more serious the symptom, coronary slow flow complicated obstructive sleep apnea may be related to MPV and CTFC.