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肺部感染对急性左心衰患者降钙素原及B型脑钠肽的影响以及相关性分析▲
Influence of pulmonary infection on serum procalcitonin and Btype natriuretic peptide in patients with acute left heart failure and the correlation between serum procalcitonin and Btype natriuretic peptide

内科 201712卷02期 页码:174-176

作者机构:肇庆医学高等专科学校内科,广东省肇庆市 526020

基金信息:▲基金项目:2015肇庆市科技创新项目(2015040308-2)

DOI:10.16121/j.cnki.cn45-1347/r.2017.02.09

  • 中文简介
  • 英文简介
  • 参考文献
目的探讨肺部感染对急性左心衰患者降钙素原(PCT)与B型脑钠肽(BNP)的影响,分析PCT与BNP的相关性。方法选择2015年1月至2016年10月我校附属医院内科收治的急性左心衰患者50例作为研究对象,按是否合并肺部感染分为单纯急性左心衰组29例,急性左心衰合并肺部感染组21例,检测比较两组患者入院后第1、7天血清PCT、BNP含量,分析PCT与BNP的相关性。结果急性左心衰合并肺部感染组患者的血清PCT、BNP水平均显著高于单纯急性左心衰组患者,差异有统计学意义(P<0.05)。 对PCT与BNP进行相关性分析结果显示,无论是入院后第1天还是入院后第7天,合并肺部感染的急性左心衰组患者血清PCT与BNP水平均呈现正相关(r=0.63,P=0.003;r=0.70,P=0.001);单纯急性左心衰组患者血清PCT与BNP水平均无相关性(r=-0.21,P=0.272;r=-0.09,P=0.640)。结论合并肺部感染可使急性左心衰患者血清PCT与BNP水平显著升高,合并肺部感染的急性左心衰患者血清PCT与BNP水平呈正相关关系,检测患者血清PCT与BNP水平有利于早期判断急性左心衰患者是否合并肺部感染以及患者心衰的严重程度。
ObjectiveTo observe the influence of pulmonary infection on serum procalcitonin (PCT) and B-type natriuretic peptide (BNP) in patients with acute left heart failure and the correlation between serum PCT and BNP. MethodsA total of 50 patients with acute left heart failure in affiliated hospital of our school from January 2015 to October 2016 were recruited and divided into acute left ventricular failure group (29 cases) and acute heart failure complicated with pulmonary infection group (21 cases) according to whether combined with pulmonary infection, the concentration of PCT and BNP in serum were compared between two groups in the first and the seventh day after admission, and the correlation between PCT and BNP was analyzed. ResultsThe levels of serum PCT and BNP in acute heart failure complicated with pulmonary infection group were significantly higher than those in acute left ventricular failure group (P<0.05). The result of correlation analysis showed that the levels of serum PCT was positive correlation with BNP in the first and the seventh day after admission(r=0.63,P=0.003;r=0.70,P=0.001)in the acute heart failure complicated with pulmonary infection group, but no correlation was found between the two in the acute left ventricular failure group (r=-0.21,P=0.272;r=-0.09,P=0.640). ConclusionsThe levels of serum PCT and BNP in acute heart failure complicated with pulmonary infection are significantly higher, that is positive correlation between the two, the measurement of PCT and BNP is useful for the early judgement on patient with acute left heart failure combined with pulmonary infection or not, and is conducive to estimated the severity of the illness.

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