ObjectiveTo study the clinical efficacy of non-invasive positive pressure ventilation combined with pipeline atomization inhalation in treatment of acute exacerbation of chronic obstructive pulmonary diseases（AECOPD) . Methods64 cases diagnosed as AECOPD but did not meet the admission to the ICU indications were randomly divided into observation group and control group, each 32 cases. The control group was given routine treatment of conventional low flow nasal catheter oxygen, cough expectorant, anti infection, correcting acid-base imbalance, respiratory stimulant, bronchodilator and nutritional support, while the observation group was treated with BiPAP ventilator and aerosol inhalation on the based of routine treatment. In each of non-invasive ventilation in the initial stage, the inhalation of combivent solution 2.5 mL, pulmicort Respules atomizing solution 2mg was done from the pipe air compressed atomizer, twice daily.The heart rate, respiratory frequency and changes of blood-gas analysis were observed in two groups, hospitalization days of two groups were also recorded. ResultsThe heart rate, respiratory frequency, PaCO2 of two groups were decreased after treatment, and pH, PaO2 were increased, but the index above in the observation group were significantly superior to control group, and the observation group had shortened hospitalization days than control group, the difference was statistically significant (P＜0.05). ConclusionsExcept for routine drug treatment, non-invasive positive pressure ventilation combined with pipeline aerosol inhalation treatment in acute exacerbation of chronic obstructive pulmonary disease can obtain satisfactory clinical effect.

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