ObjectiveTo explore the clinical effects of dingxuan granules combined with flunarizine hydrochloride in patients with vertebrobasilar insufficiency vertigo and its hemodynamic changes. MethodsA total of 160 cases of patients with vertebrobasilar insufficiency vertigo treated in our hospital from September 2013 to January 2016 were selected and divided into control group and study group according to the random number table method, with 80 cases in each group. The control group were treated with flunarizine hydrochloride, while the study group received dingxuan granules on the basis of flunarizine hydrochloride, clinical effects, hemodynamic indexes and hemorheology indexes were compared between the two groups. ResultsThe clinical effect of the study group (90.00%) was significantly higher than that of the control group (70.00%), the curative effect of the study group was significantly superior to that of the control group (P＜0.01). After treatment, the levels of LVA, RVA and BA in the two groups were significantly increased compared with those before treatment(P＜0.05), and the increased in the study group was more significant (P＜0.05 or P＜0.01); the levels of plasmic viscosity and fibrinogen of the study group were significantly lower than those of the control group (P＜0.05or P＜0.01). ConclusionsCompare to flunarizine hydrochloride, dingxuan granules combined with flunarizine hydrochloride on patients with vertebrobasilar insufficiency vertigo, can decrease the level of plasmic viscosity and fibrinogen significantly, and effectively improve hemodynamics and the curative effect.

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