【Abstract】ObjectiveTo study the clinical effect and safety of stable blood glucose levels control combined with conbercept intravitreal injection in patients with proliferative diabetic retinopathy (PDR). MethodsA total of 85 patients with proliferative diabetic retinopathy in our hospital from March 2016 to March 2017 were randomly divided into control group (43 cases) and observation group (42 cases) according to the random number method, the control group was given stable blood glucose levels control therapy, while the observation group was given conbercept intravitreal injection on the basis of the control group. BCVA, retinal thickness, VEGF, adverse reaction rate and quality of life score were compared between two groups after one month, three months of treatment and before treatment. ResultsAfter treatment, BCVA in the two groups were significantly increased compared with those before treatment, while the retinal thickness, VEGF were significantly decreased, and the increased (decreased)in the observation group was more significant (P＜0.05). The adverse reaction rate in the observation group (4.76%) was significantly lower than that of the control group (37.21%, P＜0.05).The quality of life score in the observation group was significantly higher than that of the control group (P＜0.05). ConclusionsStable blood glucose levels control combined with conbercept intravitreal injection achieves favorable effects on patients with proliferative diabetic retinopathy, and has advantages of high safety, which can improve the visual acuity and quality of life, is worth popularizing and applying.

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