【Abstract】ObjectiveTo analyze the occurrence of bacterial contamination of ventilator circuit and ventilatorassociated pneumonia (VAP) in patients with respiratory failure during mechanical ventilation therapy in ICU. MethodsA total of 120 patients with respiratory failure who received mechanical ventilation therapy in ICU in our hospital from September 2014 to March 2017 were selected as study objects. The patients were divided into contaminated group and noncontaminated group according to the results of bacterial contamination monitoring of ventilator pipelines. The general condition, incidence of VAP, mortality rate, duration of mechanical ventilation and time of hospitalization were compared between the two groups, and then the relationship between bacterial contamination of ventilator circuit and ventilatorassociated pneumonia (VAP) was analyzed. ResultsDuring mechanical ventilation therapy in ICU, the incidence of bacterial contamination of ventilator circuit was 46.7% in patients with respiratory failure . The incidence of VAP (21.43%) and mortality (17.86%) in the contaminated group were significantly higher than those in the noncontaminated group (6.25% and 4.69%, respectively), mechanical ventilation time and hospital stay in the contaminated group were significantly longer than those in noncontaminated group (P＜0.05). ConclusionsVentilator circuit is severely contaminated in patients with respiratory failure who under mechanical ventilation treatment, bacterial contamination of ventilator circuit could increase the incidence of VAP and mortality risk, and prolong duration of mechanical ventilation and hospitalization time, enough attention should be paid and timely intervention should be performed.

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