【Abstract】ObjectiveTo investigate the effect of trimetazidine (TMZ) on exercise tolerance, quality of life and cardiac function in patients with stable angina pectoris. MethodsA total of 210 patients with stable angina pectoris were randomly divided into observation group and control group, 105 in each group. All the patients were given conventional drug therapy of coronary heart disease, exercise 3～5 times a week. On the basis of these, the observation group received additional treatment with Trimetazidine Dihydrochloride, The control group with additional treatment of Oryzanol Tablets. After 8 weeks of treatment, the exercise tolerance, quality of life and improvement of cardiac function were observed and compared between the two groups. ResultsAfter 8 weeks of treatment, the MET and the 30minutes walk test of the observation group were better than those of the control group (P＜0.01); The VAS score and the number of angina attacks in the observation group were better than those in the control group (P＜0.05 or 0.01); The EF value of the observation group was higher than that of the control group, and the scores of NYHA were lower than that of the control group, Their differences were significant (P＜0.05). ConclusionOn the basis of conventional treatment, trimetazidine in the treatment of stable exertional angina pectoris can significantly increase the patients′ exercise tolerance, improve quality of life and heart function. It has important clinical significance to promote cardiac rehabilitation. It is worthy of promotion and application.

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