内科

【摘要】目的探讨常规西药联合沙参麦冬汤加减治疗慢性支气管炎患者的疗效及对炎症因子的影响。方法采用随机数字表法将82例慢性支气管炎患者分为观察组和对照组，每组41例，对照组患者给予常规西药（莫西沙星片+克拉霉素胶囊）治疗，观察组患者在此基础上给予沙参麦冬汤加减治疗。比较两组患者的临床疗效、IL1、IL6、TNFα水平变化情况和不良反应发生情况。结果观察组患者治疗总有效率为95.1%，对照组为80.5%，两组比较差异具有统计学意义（P＜0.05）。治疗后，两组患者的IL1、IL6、TNFα水平均明显降低，观察组患者的IL6、TNFα水平低于对照组，差异有统计学意义（P＜0.05）。观察组患者不良反应发生率为4.9%；对照组为21.9%，两组比较差异有统计学意义（P＜0.05）。结论常规西药联合沙参麦冬汤加减治疗慢性支气管炎患者的疗效优于单纯西药治疗，可显著降低患者炎症因子水平，减少不良反应的发生，提高临床治疗效果。

【Abstract】ObjectiveTo investigate the Effect of routine western medicine combined with Shashen Maidong Decoction in treatment of patients with chronic bronchitis and its influence on inflammatory factors. MethodsA total of 82 patients with chronic bronchitis were divided into observation group and control group by random number table method, 41 in each group. The control group was treated with routine Western Medicine (moxifloxacin and Clarithromycin), on the basis treatment of control group, the observation group was treated with Shashen Maidong Decoction. The clinical efficacy, the levels of IL1, IL6, TNFα and adverse reactions were compared between the two groups. ResultsThe total effective rate of the observation group was 95.1%, and that of the control group was 80.5%, their differences were significant (P＜0.05). The two groups of patients with IL1, IL6, TNFα levels were reduced after treatment, the levels of IL6 and TNF in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). The incidence of adverse reactions was 4.9% in the observation group and 21.9% in the control group, their differences were significant(P＜0.05). ConclusionThe clinical efficacy of the treatment of routine western medicine combined with Shashen Maidong Decoction is better than routine western medicine, and which can significantly reduce the level of inflammatory factors, reduce the incidence of adverse reactions, improve the clinical treatment effect.