内科

目的探讨益气养阴方治疗气阴两虚证慢性肾衰竭腹膜透析患者的疗效及对患者微炎症状态的影响。方法选取慢性肾衰竭腹膜透析患者106例，按照随机数字表法分为观察组和对照组，每组53例。对照组患者给予前列地尔治疗，观察组在对照组治疗的基础上服用益气养阴方治疗，两组疗程均为8周。比较两组患者的临床疗效，治疗前后的肾功能、炎症因子、主要症状积分变化以及不良反应发生情况。结果观察组患者的治疗总有效率（94.3%）显著高于对照组（73.6%），差异有统计学意义（P＜0.01）。治疗后两组患者血肌酐、尿素氮和24 h尿蛋白水平均显著降低（P＜0.05），观察组患者血肌酐、尿素氮和24 h尿蛋白水平低于对照组（P＜0.01）；治疗后两组患者IL-6、hs-CRP和IL-10水平均显著降低（P＜0.05），观察组患者IL-6、hs-CRP和IL-10水平显著低于对照组（P＜0.01）；治疗后两组患者倦怠乏力、腰膝酸软、口干咽燥、五心烦热积分均显著降低（P＜0.05），观察组患者的积分显著低于对照组（P＜0.01）。治疗过程中，两组患者均无明显不良反应发生。结论在使用前列地尔治疗的基础上加服益气养阴方治疗气阴两虚证慢性肾衰竭腹膜透析患者，可显著提高临床疗效、有效改善患者的临床症状、肾功能和微炎症状态，显著降低炎症因子水平。

ObjectiveTo explore the effect of of Yiqi Yangyin decoction on chronic renal failure of Qi Yin deficiency syndrome in patients with peritoneal dialysis and its effect on the state of micro inflammation. MethodsA total of 106 cases of peritoneal dialysis patients with chronic renal failure, which were divided into the observation group and the control group according to the random number table method. The control group were treated with alprostadil, and on the basis of this, the observation group was treated with Yiqi Yangyin decoction for 8 weeks. The clinical effects, the renal function, the inflammatory factors, the integral changes of the main symptoms and the incidence of adverse reactions were compared between the two groups. ResultsThe total effective rate of treatment in the observation group (94.3%) was higher than that of the control group (73.6%), and the difference was statistically significant (P＜0.01). After treatment, the serum creatinine, urea nitrogen and 24h urinary protein levels of the two groups were significantly decreased (P＜0.05). The serum creatinine, urea nitrogen and 24h urinary protein levels in the observation group were lower than those in the control group (P＜0.01). After treatment, the levels of IL-6, hs-CRP and IL-10 in the two groups were decreased (P＜0.05). The levels of IL-6, hs-CRP and IL-10 in the observation group were lower than those in the control group (P＜0.01). After treatment, two groups of patients with burnout weakness, soreness and weakness of waist and knees, dry mouth and throat, fanre were lower (P＜0.05). The scores of the observation group were lower than those in the control group (P＜0.01).There was no obvious adverse reaction in the two groups in the course of treatment. ConclusionOn the basis of the treatment of alprostadil, Yiqi Yangyin decoction in the treatment of chronic renal failure in peritoneal dialysis patients with Qi Yin two deficiency syndrome, which can significantly improve the clinical efficacy, improve the clinical symptoms, renal function and microinflammation, and significantly reduce the level of inflammatory factors.