ObjectiveTo observation the effect of Humalog 25R, acarbose combined with intensive lifestyle intervention in obese patients with type 2 diabetes. Methods60 obese patients with type 2 diabetes were selected in the department of endocrinology of our hospital from January 2015 to December 2015. Which was randomly divided into the observation group (30 cases) and the control group (30 cases). The observation group were given Humalog 25R, acarbose combined with intensive lifestyle intervention. The control group was treated with 70/30 only. The treatment lasted for 4 weeks. The blood glucose control, body mass index (BMI), the average dose of insulin and the incidence of adverse reactions were compared between two groups before and after treatment. ResultsBefore intervention, there was no significant difference in the levels of FPG, 2hPG, HbA1c and BMI in the two groups (P＞0.05). After the intervention, the levels of FPG, 2hPG, HbA1c and BMI in the two groups were reduced (P＜0.01). The level of 2hPG, HbA1c and BMI in the observation group was lower than that of the control group (P＜0.05). The average dosage of insulin in the patients was lower than that of the control group in the course of treatment, (P＜0.01). The rate of hypoglycemic response (3.33%) of the observation group was lower than that of the control group (26.67%). ConclusionHumalog 25R, acarbose combined with intensive lifestyle intervention in obese patients with type 2 diabetes can reduce the amount of insulin, control the level of blood sugar effectively, reduce the incidence of hypoglycemia, and reduce the status of obesity in the patients.

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