ObjectiveTo observe the clinical effect of high-dose omeprazole quadruple therapy in the treatment of Helicobacter pylori gastritis. Methods114 cases of Helicobacter pylori gastritis were selected and divided into the control group and the observation group by the random digital table method, with 57 cases in each group. The control group were treated with the conventional dose of omeprazole, and the observation group were treated with high-dose omeprazole quadruple therapy. The two groups were treated for 2 weeks. The clinical effect, the symptom score before and after the treatment and the occurrence of adverse reaction were compared between the two groups. ResultsThe total effective rate of treatment was 87.72% in the observation group and 70.18% in the control group. The clinical efficacy of the observation group was significantly better than that of the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in the symptom score of the two groups before treatment, (P＞0.05). The symptom scores of the two groups were obviously decreased, and the symptom scores of the observation group were significantly lower than those in the control group after treatment, the difference was statistically significant (P＜0.05). In the course of treatment, there were a few patients with slight dizziness, headache, diarrhea, nausea, vomiting and other adverse reactions in the two groups of patients. ConclusionThe clinical efficacy of high dose omeprazole quadruple therapy is significant in the treatment of Helicobacter pylori gastritis. It can effectively relieve the clinical symptoms of the patients, and will not increase the adverse reaction of the patients.

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