内科

目的探讨门冬氨酸鸟氨酸联合纳洛酮治疗急性酒精中毒患者的疗效。方法选取我院2016年3月至2017年9月诊治的急性酒精中毒患者96例为研究对象，按随机数字表法分成对照组和研究组，每组48例。两组患者均给予吸氧、输液、保暖、外伤处理等基础治疗。在基础治疗上，对照组患者给予纳洛酮0.4～0.6 mg静脉滴注治疗；研究组患者在对照组患者治疗的基础上给予门冬氨酸鸟氨酸5～10 g静脉滴注治疗。比较两组患者的临床疗效，两组患者兴奋期、共济失调期、昏迷期症状消失时间及意识完全恢复时间，检测比较两组患者血清中谷丙转氨酶（ALT）和谷草转氨酶（AST）水平，观察比较两组患者呼吸抑制加重、呕吐、心动过快、嗜睡、烦躁不安等不良反应发生情况。结果研究组患者的治疗总有效率为95.83%，对照组为77.08%；研究组患者的临床疗效优于对照组，差异有统计学意义（P＜0.01）。研究组患者兴奋期、共济失调期、昏迷期症状消失时间及意识完全恢复时间均显著短于对照组（P＜0.01）。治疗后，研究组患者血清ALT、AST水平均明显降低，且显著低于对照组（P＜0.01）。研究组患者不良反应发生率（4.16%）显著低于对照组为（20.83%），差异有统计学意义（P＜0.01）。结论门冬氨酸鸟氨酸联合纳洛酮治疗急性酒精中毒患者能促进患者意识恢复，有效减轻肝损伤，临床疗效显著，治疗安全性高。

ObjectiveTo investigate the efficacy of aspartate ornithine combined with naloxone in the treatment of patients with acute alcoholism. Methods96 patients with acute alcoholism in our hospital from March 2016 to September 2017 were divided into the control group and the study group according to the random digital table method, with 48 cases in each group. The two groups were given basic treatment, such as oxygen inhalation, infusion, heat preservation, and trauma treatment. In the basic treatment, the control group were treated with naloxone 0.4-0.6 mg intravenous drip treatment. The study group were treated with aspartate ornithine 5-10 g intravenous drip on the basis of treatment in the control group. The clinical efficacy of both groups was compared. The symptoms of excitability, ataxia, coma period, and conscious recovery time were compared in both groups. Compared two groups of patients with serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. The incidence of adverse reactions, such as respiratory depression, vomiting, tachycardia, lethargy and irritability, was observed and compared between the two groups. ResultsThe total effective rate of treatment was 95.83% in the study group and 77.08% in the control group. The clinical effect of the study group was better than that of the control group, and the difference was statistically significant (P＜0.01). The period of excitability, ataxia, coma period and complete recovery of consciousness were significantly shorter in the study group than in the control group (P＜0.01). After treatment, the serum levels of ALT and AST in the study group were significantly lower, and significantly lower than that of the control group (P＜0.01). The incidence of ADR in the study group (4.16%) was significantly lower than that of the control group (20.83%), and the difference was statistically significant (P＜0.01). ConclusionAspartate ornithine combined naloxone in the treatment of patients with acute alcohol intoxication can promote the recovery of patients′ consciousness. It can reduce the liver injury, the clinical curative effect is remarkable, the treatment safety is high.