ObjectiveTo investigate the effects of clopidogrel combined with aspirin on cardiac function and major adverse cardiovascular events (MACE) in patients with acute ST elevation myocardial infarction（stEMI）. Methods150 patients with acute stEMI treated in our hospital from March 2015 to May 2017 were selected and randomly divided into observation group and control group, 75 cases in each group. The control group were treated with aspirin. The observation group were treated with clopidogrel and aspirin. The two groups were treated with 28 d. The changes of cardiac function index, creatine kinase（CK） and creatine kinase isozyme MB（CKMB） before and after treatment were compared between the two groups. MACE and adverse reaction after treatment were compared between the two groups. ResultsAfter the treatment, the cardiac function indexes of the two groups were improved. The cardiac function index of the observation group was better than that of the control group, and the difference was statistically significant (P＜0.01). The levels of CK and CKMB in the two groups were lower than those before the treatment. The level of CK and CKMB in the observation group was lower than that of the control group (P＜0.01). The incidence of MACE events in the observation group (5.33%) was significantly lower than that of the control group (18.67%) (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.01). ConclusionClopidogrel combined with aspirin in the treatment of stEMI patients can effectively improve the cardiac function of the patients, and reduce the occurrence of MACE events. But there was no increase in the incidence of adverse reactions.

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