ObjectiveTo investigate the effect of low dose folic acid combined with antihypertensive drugs on blood homocysteine (Hcy) level and carotid intima media thickness (CIMT) in patients with “H” type hypertension. Methods150 cases of elderly “H” hypertension patients were selected from January to May 2016 in our hospital, and randomly divided into the control group and the observation group, 75 cases in each group. The control group were treated with routine antihypertensive, and the observation group were treated with low dose of folic acid on the basis of the control group, 0.8 mg/d. The blood Hcy level and the thickness of CIMT were compared between the two groups before treatment and third, sixth, twelfth months after treatment. ResultsThere was no significant difference in the blood Hcy level between the two groups before treatment (P＞0.05). After third, sixth, twelfth months of treatment, the blood Hcy level of the patients in the observation group was lower than that of the control group, the difference was statistically significant (P＜0.01). Before treatment and third months after treatment, there was no significant difference in CIMT between the two groups (P＞0.05). After sixth, twelfth months of treatment, the CIMT in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P＜0.05). ConclusionRoutine antihypertensive drugs combined with oral low dose folic acid treatment can effectively reduce the blood Hcy level of H type hypertension patients and slow down the progress of carotid intima, which is worthy of clinical application.

无