ObjectiveTo investigate the effect of Xuebijing combined with prostaglandin E1 in treatment of patients with diabetic nephropathy and its effect on serum inflammatory factor 3. Methods160 patients with diabetic nephropathy treated in our hospital from May 2014 to May 2016 were selected. According to the random number table method, the control group and the observation group were divided into the control group and the observation group, with 80 cases in each group. The control group were given routine and routine treatment, and the observation group were treated with Xuebijing combined with prostaglandin E1 on the basis of routine treatment. The levels of urine protein, urine microalbumin, serum TNF-alpha and MCP-1 were compared before and after treatment in the two groups. ResultsThere was no significant difference in the levels of urine protein, urine microalbumin, serum TNF-alpha and MCP-1 in the two groups before treatment (P＞0.05). After treatment, the levels of urine protein, microalbuminuria, serum TNF-alpha and MCP-1 in the observation group were lower than those of the control group (P＜0.01). The clinical efficacy of the observation group was better than that of the control group, and the total effective rate (82.5%) was significantly higher than that of the control group (55%), and the difference was statistically significant (P＜0.01). ConclusionIt is suggested that on the basis of routine treatment, Xuebijing combined with prostaglandin E1 in the treatment of diabetic nephropathy can effectively reduce the level of inflammatory factors, reduce renal damage, delay the development of disease and improve the clinical effect.

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