ObjectiveTo analyze the adverse drug reactions caused by the combination of statins and other drugs, so as to provide guidance for rational use of drugs in clinical practice. MethodsMethods the clinical data of 94 patients who took statin lipid-lowering drugs combined with other drugs in our hospital from March 2016 to June 2017 were retrospectively analyzed. ResultsThe highest ratio of muscle toxicity (35.11%) was found in 94 patients with adverse drug reactions. Hepatotoxicity and adverse reaction of digestive system were25.53% and 19.15%. The ratio of rhabdomyolysis was 25.53%. Statins include simvastatin, atorvastatin, lovastatin, pravastatin, fluvastatin, and rosuvastatin. The ratio of Simvastatin to drug adverse reaction was 41.49%, and the second was atorvastatin 29.79%. Statins combined with anti myocardial ischemia drugs or antihypertensive drugs, anticoagulants or antiplatelet agents, Bette lipid lowering drugs, antiviral drugs, antibacterial agents, antidiabetic drugs, injections or proprietary Chinese medicines, can cause adverse reactions. The combination of anti myocardial ischemia drugs or antihypertensive drugs is the most common adverse reaction (27.66%), followed by anticoagulant/antiplatelet drugs or combined with beats lipid regulating drugs (20.21% and 17.02%). The incidence of adverse drug reactions in male patients (56.38%) is slightly higher than that in females (43.62%), and the probability of adverse drug reactions in 70-79 years old patients is higher than that in other age groups. ConclusionSimvastatin and atorvastatin represent a high risk of adverse reactions when combined with anti myocardial ischemia, antihypertensive, anticoagulation and antiplatelet drugs. The main manifestations are hepatotoxicity and muscle toxicity, and the age of the patients is an important factor.

无