Objective To investigate the clinical efficacy of andrographolide combined with fiberoptic bronchoscopy in the treatment of acute exacerbation of bronchiectasis. Methods142 cases of acute exacerbation of bronchiectasis were selected and were randomly divided into observation group and control group, with 71 cases in each group. The control group were treated with fiberoptic bronchoscopy, and the observation group were treated with andrographolide Capsule on the basis of bronchoscopy irrigation. The clinical effects of the two groups were compared. ResultThere was no significant difference in the level of IL-6 and Hs-CRP between the two groups before treatment(P＞0.05). After treatment, the levels of IL-6 and Hs-CRP in the two groups were significantly decreased (P＜0.01). The level of IL-6 and Hs-CRP in the observation group was significantly lower than that of the control group (P＜0.01). The disappearance time of the symptoms in the observation group was significantly shorter than that of the control group (P＜0.05), such as wheezing, cough, lung rale and expectoration. ConclusionAndrographolide combined with bronchoscopy lavage in the treatment of acute exacerbation of bronchiectasis can significantly reduce the level of inflammatory factors and improve the clinical effect.

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