ObjectiveTo investigate the correlation between carotid atherosclerotic vulnerable plaque and blood homocysteine (Hcy) and blood lipid levels. MethodA total of 269 patients with carotid atherosclerosis who underwent cervical vascular ultrasonography were selected as subjects. According to the results, the carotid atherosclerotic stable plaque group (SP group, 106 cases) and the carotid atherosclerotic vulnerable plaque group (VP group, 163 cases) were selected. Serum Hcy levels and blood lipid levels were compared between the two groups. Multivariate logistic regression analysis was performed on the factors affecting the occurrence of vulnerable plaque. ResultsThe age, male ratio, TC, LDL-C, lipoprotein(a), and Hcy levels in the VP group were higher than those in the SP group, and the HDL-C was lower than that in the SP group. The difference was statistically significant (P＜0.05). The proportion of patients with high homocysteinemia in the VP group was significantly higher than that in the SP group (P＜0.05). Multivariate logistic regression analysis showed that age, high Hcy level and high LP(a) level were risk factors for vulnerable plaque. Female and high HDL-C levels were protective factors for vulnerable plaque. ConclusionAge, high Hcy level, and high LP(a) levels are risk factors for carotid atherosclerotic vulnerable plaque. HHcy is an independent risk factor for carotid vulnerable plaque formation. Lowering Hcy level reduces carotid atherosclerosis. The process of hardening may have a positive effect.

无